T-ALL tumor cells exhibit transcriptional profiles distinct from those of normal circulating blood cells, with abnormalities related to the cell cycle regulation, tumor suppressor gene expression, epigenetic regulation, RNA processing, ribosomal function, ubiquitination, Ras signal transduction, JAK-STAT signaling, PI3K-AKT-mTOR signaling, and Notch1 signaling pathways, among others. This evidence concerns the gene NOTCH1 and neoplasm.