COL1A1 and interstitial lung disease: Genes associated with regulation of extracellular matrix formation and remodeling including Collagen 1A1 (Col1A1), N-Cadherin 2 (CDH2) and Vimentin (VIM) showed increased expression in alveolar organoids co-cultured with ILD fibroblasts in high seeding ratios (Figure 2B).