In conclusion, this study shows systemic effects of morbid obesity characterized by persistence of a low-grade chronic inflammation and a dysregulation of lipids, adipocytokines and gastrointestinal hormone ghrelin as well as disturbed peripheral blood immune cells indicated by increased levels of mo-MDSCs, decreased NK cells, and decreased levels of CD4+ naïve T cells. The gene discussed is CD4; the disease is morbid obesity.