As shown in Table S2, patients with advanced liver fibrosis were older (54.0 vs. 52.0, P = 0.035) and had higher median levels of total bilirubin (TB, 25.5 μmol/L vs. 16.2 μmol/L, P = 0.008), RDW (14.0% vs. 13.6%, P = 0.023), and prothrombin time (PT, 13.5s vs. 12.4s, P <0.001) compared to patients with non-advanced fibrosis, while lower median levels of albumin (ALB, 36.7 g/L vs. 38.8 g/L, P = 0.003) and PLT (132.0 × 109/L vs. 177.0 × 109/L, P <0.001) were found. The gene discussed is F2; the disease is fibrosis.