ADAM10 and Alzheimer disease: As mentioned above, ADAM10 plays a critical role in the pathology of AD, and as it has a wide range of substrates, it is also an integral part of health and disease (Pruessmeyer and Ludwig, 2009; Saftig and Lichtenthaler, 2015; Kuhn et al., 2016; Wetzel et al., 2017; Smith et al., 2020).