Concentrations of CXCL1 were significantly elevated in dogs with stroke (mean = 436 pg/ml, median = 466 pg/ml, range = 157–681 pg/ml) compared to control dogs (mean = 267 pg/ml, median = 267 pg/ml, range = 210–352 pg/ml) (p = 0.01). This evidence concerns the gene CXCL1 and stroke disorder.