However, none of the genes expressing a circRNA with a strong correlation to Alzheimer’s disease (HOMER1, DOCK1, KCNN2, ICA1, RMN1, ATRNL1, ST18, MAN2A1, EXOSC1, and RTN4) expressed a regulated retained intron. Here, KCNN2 is linked to early-onset autosomal dominant Alzheimer disease.