Primarily, Aβ42 (Li et al., 2022), P-tau (Palmqvist et al., 2020), APOE4 (for AD) (Palmqvist et al., 2023), α-synuclein (for PD) (Niu et al., 2020), many miRNAs (for AD (Wiedrick et al., 2019), addiction (Chand et al., 2021), SCZ (Du et al., 2019), GBM (Ebrahimkhani et al., 2018)) were discovered in the isolated EVPs. Here, APOE is linked to Alzheimer disease.