MAPT and Alzheimer disease: EVPs isolated from the CSF and blood of patients with AD and PD have been found to contain protein aggregates of Aβ, tau, and α-synuclein (Joshi et al., 2014; Guix et al., 2018; Cicognola et al., 2019; Niu et al., 2020; Upadhya et al., 2020; Li et al., 2022).