HIF1A and colorectal carcinoma: The analysis of KEGG pathway in this study suggests that vitamin D3 may exert pharmacological effects by simultaneously regulating different CRC-related signaling pathways, such as FoxO signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, etc. These results support that vitamin D3 may mediate the inhibition of HIF-1 through inhibition of the upstream PI3K-AKT pathway.