Angiotensin receptor type 1 (AT1R), a G-protein coupled receptor, mediates the effect of angiotensin-II and contributes to pathophysiological consequences such as vascular remodeling, hypertension, and end-organ damage (Mehta and Griendling, 2007; Forrester et al., 2018). The gene discussed is AGTR1; the disease is Hypertension.