tularensis LVS-infection (Table 1A); a significant upregulation of genes involved in RAS pathway including Ccl2, Nfkb, p38 Mapk, Ras, Stat1, Stat3 and Tnf-α (Table 1B); and an upregulated expression of IFN-γ pathway genes such as Bak, Bax, Ifit, Ifn-γ, Irf, Isg, Oas1, Psmb8, Ptpn2, Stat and Tap1 (Table 1C). Here, PSMB8 is linked to infection.