The majority of the studies related to cytosolic recognition of Francisella and activation of the AIM2 inflammasome have been done using F. novicida. Once the host cell is infected with F. novicida, a robust AIM2-dependent inflammasome response is induced, culminating in the production of a potent proinflammatory cytokine response and pyroptosis to clear the infection. This evidence concerns the gene AIM2 and infection.