T2DM, HbA1C between 7.0% and 11.0%, with ≥3 months metformin, sulfonylureas, thiazolidinediones, glinides, SGLT-2 inhibitor or alpha-glucosidase inhibitor, BMI of ≥23 kg/m2, stable body weight ≥3 months with no exercise/intensive diet for body weight reduction. This evidence concerns the gene GAA and type 2 diabetes mellitus.