T2DM, insulin naive, HbA1C = 7.0% to 10.5%, stable metformin (≥1,500 mg/day) or metformin and SGLT-2 inhibitor treatment ≥3 months, stable body weight ≥3 months, BMI of ≥25 kg/m2. This evidence concerns the gene INS and type 2 diabetes mellitus.