HbA1C = glycated hemoglobin; BMI = body mass index; FSG = fasting serum glucose; DPP4 = dipeptidyl peptidase-4; OAM = oral antihyperglycemic medication; MACE = major adverse cardiovascular event; SAE = severe adverse event; SGLT-2 = sodium glucose cotransporter; RCT = randomized controlled trials; T2DM = type 2 diabetes mellitus; HOMA = homeostasis model assessment; HDL = high density lipoprotein; VLDL = very low density lipoprotein; LDL = low density lipoprotein; NCT = National Clinical Trial; SC = subcutaneous. The gene discussed is DPP4; the disease is diabetes mellitus.