IL6 and obesity due to melanocortin 4 receptor deficiency: Obesity caused by HFD can lead to chronic systemic inflammation, activate signal pathways, and promote the progression of PCa through immune system-related mechanisms, including activating a series of chemical signaling pathways such as IL6/pSTAT3 or MCP-1/CCR2, inhibiting the tumor suppressor gene PTEN to induce the growth of PCa (113), and inducing local IL-6 upregulation in immune cells and MDSC, enhanced MYC transcriptional programming through metabolic changes increases histone hypomethylation in the promoter region of the MYC regulatory gene (114).