showed that both ruminococcus and A.muciniphipla are involved in steroid biosynthesis, and the relative abundance of A.muciniphipla and ruminococcus is higher in PCa patients taking ATT, which they believe is more beneficial to the efficacy of anti-programmed death-1 (PD-1) immunotherapy, while the use of antibiotics in patients with ruminococcus will increase the risk of progressive PCa (174). The gene discussed is PDCD1; the disease is posterior cortical atrophy.