gave PCa mice on a high-fat diet (HFD) an oral antibiotic mixture and found that the number of Rikenellaceae and Clostridiales increased and the composition of intestinal microflora was significantly different from that of the control group, which inhibited the proliferation of PCa cells and decreased the expression of Igf1 and the level of circulating insulin-like growth factor-1 (IGF1) in the prostate (37). The gene discussed is IGF1; the disease is posterior cortical atrophy.