IGF1 and acromegaly: IGF1 can also directly promote the proliferation of PCa cell lines DU145 and 22RV1 in vitro (37),The incidence of PCa and the risk of PCa-related mortality are also significantly increased in acromegaly patients with systemic high growth hormone and IGF-1 levels, indicating that IGF-1 plays a positive role in the development and progression of PCa (54).