Obesity caused by HFD can lead to chronic systemic inflammation, activate signal pathways, and promote the progression of PCa through immune system-related mechanisms, including activating a series of chemical signaling pathways such as IL6/pSTAT3 or MCP-1/CCR2, inhibiting the tumor suppressor gene PTEN to induce the growth of PCa (113), and inducing local IL-6 upregulation in immune cells and MDSC, enhanced MYC transcriptional programming through metabolic changes increases histone hypomethylation in the promoter region of the MYC regulatory gene (114). This evidence concerns the gene MYC and obesity due to melanocortin 4 receptor deficiency.