Another example of how TAMs are able to induce drug resistance is provided by Niu X. et al., reporting that the M2-TAMs activate the EGFR/PI3K/Akt pathway and, consequently, the sodium/glucose cotransporter 1 (SGLT1) expression to promote tamoxifen resistance in ER-positive BC cells (65). The gene discussed is AKT1; the disease is breast cancer.