In particular, CAF secrete the C-X-C Motif Chemokine Ligand 12 CXCL12 attracting and retaining both myeloid (76) and CD4+/CD25+ T cells in the tumor, ultimately promoting their differentiation to Tregs immune cells and their survival via the expression of T cell interacting proteins (58, 75). The gene discussed is CXCL12; the disease is neoplasm.