CSF3 and cancer: In cancer, several soluble molecules, such as such as for example granulocytic-colony stimulating factor (G-CSF), C-X-C chemokine ligand (CXCL)2, CC-chemokine ligand (CCL)2, CCL5, CXCL5, and CXCL12 secreted by the tumor cause the block of myeloid differentiation, affecting their mobilization from the bone marrow and infiltration into the primary and secondary tumors (3).