IL4 and central nervous system cancer: Schwartzbaum and colleagues found an association with reduced soluble interleukin 4 receptor alpha (sIL4RA) (OR=0.92, 95% CI=0.76-1.12) and elevated IL4-sIL4RA (OR=1.37, 95% CI=1.16-1.61) with increased risk of glioma in the JSB (12).