CRH and Anxiety: HPA axis disorders are common in animal models of anxiety, and JWXYS can normalize the HPA axis by decreasing the plasma levels of corticosterone (CORT), corticotropin-releasing hormone (CRH), and adrenocorticotropic hormone (ACTH) and increasing arginine vasopressin (AVP) levels in animals (Cao, Gui, Fu, Guo, & Fu, 2016, Wu et al., 2016).