Taking negatively correlated FGF9 and GBP1 as an example, FGF9 has been confirmed to promote M2 polarization in a variety of diseases (56, 57), At the same time, GBP1 has been verified to participate in M1 polarization in a variety of infectious diseases (56, 58), and is considered to be capable of regulating the polarity of M1/M2 macrophages in the tumor microenvironment (59). Here, GBP1 is linked to infectious disease.