MPO and atherosclerosis: NETs are released into the extracellular space along with other granule proteins, including neutrophil elastase (NE), myeloperoxidase (MPO), and caseinase G. This excretion of DNA generates a pro-oxidative, pro-inflammatory and pro-thrombotic environment that can induce endothelial damage (19), which is also associated with atherosclerosis, coronary artery disease (CAD), endotoxic shock and target organ damage (20–22), leading to cardiovascular events.