NETs are released into the extracellular space along with other granule proteins, including neutrophil elastase (NE), myeloperoxidase (MPO), and caseinase G. This excretion of DNA generates a pro-oxidative, pro-inflammatory and pro-thrombotic environment that can induce endothelial damage (19), which is also associated with atherosclerosis, coronary artery disease (CAD), endotoxic shock and target organ damage (20–22), leading to cardiovascular events. The gene discussed is ELANE; the disease is atherosclerosis.