An absence of MUC2 mucin expression was closely related to high methylation modification of the MUC2 promoter and a glycosylation defect of the MUC2 gene in CRC cells (Yonezawa and Sato, 1997; Biemer-Hüttmann et al., 2000). The gene discussed is MUC5AC; the disease is colorectal carcinoma.