GRD include: (1) autoimmune reactions, e.g., coeliac disease (CD), dermatitis herpetiformis (DH) and gluten ataxia; (2) IgE-mediated allergy, e.g., wheat allergy (WA) and 3) immune-mediated non-coeliac gluten sensitivity (NCGS) (2). The gene discussed is IGHE; the disease is allergic disease.