A decrease in expression of the Kir6.1 and SUR2B subunits of vascular-type KATP channels is often accompanied by arterial hypertension [29], whereas an increase in expression of these subunits is associated with an increase in vasodilator responses to pharmacological openers of these channels and a decrease in arterial pressure [11]. The gene discussed is KCNJ8; the disease is Hypertension.