JAK inhibitors are an attractive small molecule option given the widespread signaling of cytokines and growth factors using JAK-STAT receptors in asthma, including IL-4, IL-5, IL-13, GM-CSF, IFN-α, IFN-β, IFN-γ, and TSLP (Georas et al., 2021). The gene discussed is IL4; the disease is asthma.