Depending on the knowledge of the trimester of infection, the percentages of the presence of the infant IgM triplet or its absence were: for the first trimester 43.8% (7/16) versus 56.2% (9/16), the second 37.8% (28/74) versus 62.2% (46/74), the third 67.7% (90/133) versus 32.3% (43/133), and when unknown 42.9% (15/35) versus 57.1% (20/35). The gene discussed is CD40LG; the disease is infection.