[68Ga]Ga-NOTA-MI-exendin-4 showeda renal uptake thatwas 70% lower than [68Ga]Ga-NOTA-exendin-4 in BALB/c nudemice, while the radiotracer uptake in the INS-1 tumor was preserved,which could potentially increase the sensitivity of GLP-1R PET/CTto detect insulinomas. The gene discussed is GLP1R; the disease is pancreatic insulinoma.