Furthermore,recent studies suggest that this imaging method is preferred oversomatostatin receptor scintigraphy and may be considered for the localizationof insulinomas instead of somatostatin PET/CT.4,6 Exendin-4is a stable analogue of the natural, unstable GLP-1 ligand, bindswith high affinity to the GLP-1R,7 andshows high accumulation in insulinomas upon intravenous administration.However, radiolabeled exendin-4 also shows a high renal uptake asa result of tubular reabsorption in the kidneys.8 This evidence concerns the gene GCG and pancreatic insulinoma.