PET imaging of the glucagon-like peptide-1 receptor (GLP-1R)usingradiolabeled exendin is a promising imaging method to detect insulinomas.However, high renal accumulation of radiolabeled exendin could hamperthe detection of small insulinomas in proximity to the kidneys andlimit its use as a radiotherapeutic agent. This evidence concerns the gene GLP1R and pancreatic insulinoma.