Interestingly though, ALK1, BMP9/BMP10 and endoglin knockout in adult mice similarly result in high-output heart failure, as does Bmp10 deficiency in zebrafish (Bouvard et al., 2022; Capasso et al., 2020; Morine et al., 2017; Tual-Chalot et al., 2020). This evidence concerns the gene ACVRL1 and heart failure.