PITX2 and atrial fibrillation: Variants on the PITX2 locus were also reported in GWAS meta-analysis of HF highlighting the link of AF and HF.35 If AF is the mediator of the observed increased risk for HF with genetic stroke risk, as suggested by partially shared genetic architecture (PITX2) across all three conditions, the observed HF events might be tachymyopathy-driven events.