NFKB1 and immune system disorder: Although the role of toxoplasmosis and Epstein-Barr virus infection in the pathogenesis of BD is less well understood, some studies have demonstrated that toxoplasmosis and Epstein-Barr virus infection are the risk factors for other systemic immune diseases, including rheumatoid arthritis and systemic lupus erythematosus [36, 37], and were associated with the activation of the NF-κB signaling pathway [38, 39].