The downregulated DEPs were mainly enriched in NF-kappa B, toxoplasmosis, arrhythmogenic right ventricular cardiomyopathy, ECM-receptor interaction, and hypertrophic cardiomyopathy signaling pathway, and the upregulated DEPs were mainly enriched in C-type lectin receptor, malaria, intestinal immune network for IgA production, graft-versus-host disease, and African trypanosomiasis signaling pathway in the KEGG pathway analyses, respectively (P.adjust < 0.05). The gene discussed is CLEC4D; the disease is human African trypanosomiasis.