LRRK2 and Parkinson disease: In another patient from a family of autosomal dominant Parkinson’s disease due to LRRK2 p.R1441C, Parkinsonism and supranuclear gaze palsy were observed, and neuropathologic evaluation of this patient revealed PSP-like tau pathology, including globose tangles in the subthalamic nucleus and tufted astrocytes in the midbrain tectum [41].