MAPT and supranuclear palsy, progressive, 1: Both PSP and CBD are characterized by aggregates of hyperphosphorylated tau protein in neurons (i.e., pretangles and globose tangles), oligodendrocytes (i.e., coiled bodies) and astrocytes (i.e., tufted astrocytes and astrocytic plaques) in cortical and subcortical structures [7, 29].