ESR1 and neoplasm: Based on the backward stepwise selection method in the multivariate logistic regression analysis (Table 2), eight variables were associated with ALN metastasis and they were assigned scores for the final prediction rule: AJCC stage [II (1.0 points), III (17.5 points), IV (16.0 points)], T stage [T2 (1.0 points), T3 (17.0 points), T4 (2.0 points)], ER (positive,16.0 points), HER-2 (positive,1.5 points), maximum tumor diameter(≥ 3.55 cm,1.0 points), Kep (≥ 0.982 min−1,1.0 points), Ve (≥ 0.253, -0.5 points), and TTP (≥ 0.778 min−1,1.0 points).