CASC3 and neoplasm: Although the amount of BTZ in the intra-tumoural injection was the same as the total amount of drug loaded in the scaffold, the anti-tumor effect displayed a significant difference (p < 0.05), indicating that the intra-tumoral injection of BTZ was less effective than that of the sustained release from BTZ/nHA@SA scaffold and some injected BTZ may be leaked into systemic circulation metabolism.