VEGFA and hyperinsulinemic hypoglycemia, familial, 4: Several studies have demonstrated tangible mRNA therapies, such as the regeneration of VEGF-A protein for diabetes [72], restoration of tumor suppressors for cancer treatment [73, 74], delivery of ARG1 mRNA liver-targeted NPs for arginase deficiency [23], and mRNA vaccines for COVID-19 by Moderna, Inc[22].