Tang et al. found that the eraser ALKBH5 removed the m6A modification in the 3’UTR of WIF-1 mRNA to promote its transcription and inhibited Wnt signaling by upregulating Wnt inhibitory factor 1 (WIF-1) instead of regulating β-catenin expression, which makes pancreatic ductal adenocarcinoma (PDAC) cells less sensitive to gemcitabine. This evidence concerns the gene WIF1 and pancreatic ductal adenocarcinoma.