MAP2K1 and major depressive disorder: For some examples, Wang figured out the key components of Chai-Hu-Shu-Gan-San and decoded the mechanism of treating depression by regulating downstream genes through protein kinase A or C to treat depression after cascade signal changes [12]; Chen found critical ingredients and mechanisms of Xuebijing injection in treating sepsis synergistically by affecting genes such as TAK1, TNF-α, IL-1β, and MEK1 in the MAPK, NF-κB, PI3K-AKT, Toll-like receptor, and TNF signaling pathways [13].