Moreover, we found that GDM patients carrying the T allele of C-1054T variation had lower TG levels and TG/HDL-C ratio but higher fasting insulin and HOMA-IR than those carrying the CC genotype; GDM patients carrying the DD/TT + CT or II + ID/TT + CT combined genotype had higher fasting Glu or Ins levels and HOMA-IR values, and those with the II + ID/CC genotype had higher TG and TG/HDL-C ratio, implying that the C-1054T and 96-bp I/D variants in CYP2E1 may be linked to lipid metabolism, hyperinsulinemia, and insulin resistance in the patients. This evidence concerns the gene CYP2E1 and hyperinsulinism.