TNF and breast cancer: Together with the overexpression of mouse double minute 2 (MDM2), it has a role in BC via the augmentation of BC invasion and migration through negatively regulating P53 [36, 37] as well as tumor necrosis factor α (TNFα) which elicits inhibition of cell proliferation, induction of apoptosis, or even the enhancement of cell migration, as well as contributing to poor prognosis outcomes [38].