The upregulated CKD-related pathogenic genes in the calcified valve were applied to cMAP analysis, and 10 small-molecular compounds (metyrapone, gefitinib, dilazep, aminopentamide, methoxsalen, forskolin, CGP-37157, IKK2-inhibitor, vidarabine and TG-101348) were selected as candidates. Here, IKBKB is linked to chronic kidney disease.