Quinazoline-4-piperidine sulfamides (QPS) have been depicted as the inhibitors of Ectonucleotide pyrophosphatase/PDE1 (NPP1), which can attenuate the high phosphate-induced mineralization in a cellular model of CAVD [40]. This evidence concerns the gene ENPP1 and congenital bilateral aplasia of vas deferens from CFTR mutation.