CYP2E1 genetic polymorphism affects the susceptibility of multiple tumors [20, 21], while CSMD3 mutation is significantly linked to prognosis in some cancers such as non-small cell lung cancer [22], esophageal squamous cell carcinoma [23], but their specific mechanism still needed further exploring. The gene discussed is CSMD3; the disease is esophageal squamous cell carcinoma.