ABT869 exhibits anti-proliferative effects in multiple cancers with FMS-like tyrosine kinase 3–internal tandem duplication (FLT3-ITD) (e.g., acute myeloid leukemia) by inhibiting phosphorylation of FLT3, STAT5, and ERK, consequently inducing apoptosis (Shankar et al. 2007). This evidence concerns the gene FLT3 and acute myeloid leukemia.