In men of European ancestry in the UKB excluded from the PSA GWAS, there was a strong positive relationship between the 269-variant prostate cancer PGS (PGS269)32 and PGSPSA in cases (n = 11,568, β = 0.190, P = 2.3 × 10−96) and controls (n = 152,884, β = 0.236, P < 10−700) (Extended Data Fig. 5 and Supplementary Table 13). Here, KLK3 is linked to Familial prostate cancer.