KLK3 and Familial prostate cancer: Genetically adjusted PSA was more predictive of aggressive prostate cancer (odds ratio (OR) = 3.44, P = 6.2 × 10−14, area under the curve (AUC) = 0.755) than unadjusted PSA (OR = 3.31, P = 1.1 × 10−12, AUC = 0.738) in 106 cases and 23,667 controls.