MAPT and Alzheimer disease: It is worth noticing that although tau has ~85 putative phospho-sites and a large portion of them (>40 sites) are found to be hyperphosphorylated in AD, of which each kinase targets a handful of sites that it can phosphorylate, the choice of analysed phosphor-sites (as low as one or two in some studies [132, 141]) limits the interpretability of these results.