MAPT and Alzheimer disease: Among these, the 3xTg AD model shows tau pathology in the hippocampus, particularly pyramidal neurons, where JNPL3(P301L) homozygous and heterozygous mice and P301S mice develop neuronal inclusions reminiscent of tangles and Pick-bodies by 4.5 and 6, and 6 months respectively [185, 186].