In our datasets, although the gene activity and RNA expression level of IRF3 showed minimal changes (Figs. S7A, and B), the motif activity of IRF3 and IRF7 was decreased at myocarditis state across all cell subpopulations except for pDCs and memory B cells (Figs. 3B–D, and S7C). This evidence concerns the gene IRF7 and myocarditis.