According to the analysis of LKB1 expression and lymph node metastasis, high LKB1 expression was associated with lymph node metastasis of GC (present vs. absent, OR 0.487; 95% CI 0.397–0.598; P = 0.01, I2 = 67.1%) (Fig. 7). The gene discussed is STK11; the disease is metastatic malignant neoplasm in the lymph nodes.