Because absence of core fucosylation (afucosylation) significantly increase the monovalent affinity of IgG to FcγRIIIA23, it can be assumed that afucosylated Fc will efficiently occupy FcγRIIIA and will be beneficial for inducing anti-inflammatory activity and treatment of refractory ITP. Here, FCGR3A is linked to autoimmune thrombocytopenic purpura.