Considering that a previous study has shown that citrullinated fibrinogen and citrullinated vimentin are associated with increased aortic plaque5, and both proteins can be detected in the same region around the 56 kDa marker, we can propose fibrinogen and vimentin as candidates of the main target protein in the citrullination process related to the pathophysiology of AS. The gene discussed is VIM; the disease is aortic stenosis.