SLC28A1 and leukemia: In addition to fluoropyrimidine anticancer agents, CNT1 also transports several DNA methyltransferase inhibitors (e.g., 5-azacytidine, decitabine, zebularine), which are currently used to treat various leukemias, such as acute myeloid leukemia and chronic lymphocytic leukemia67,68 Moreover, recent studies have demonstrated significantly reduced expression levels of CNT1 in leukemic tissues, which may further worsen the predictability of the outcome of these drugs30.