Notably, orthotopic injection of a Kras/p53-mutated mouse PDAC cell line (KPC) into syngeneic WT mice allows the rapid development of pancreatic tumors with a severe metastatic burden that results in complete mortality within 3–5 weeks of implantation56, and administration of dFdC dramatically reduces tumor burden to delay mortality. Here, TP53 is linked to pancreatic neoplasm.