We reported previously that circGSK3β promoted ESCC cell migration and invasion via directly interacting with GSK3β and inhibiting GSK3β activity [16], and hsa_circ_0006948 enhances ESCC progression and epithelial-mesenchymal transition through the miR-490-3p sponge [17], indicating that circRNA plays an important role in the development of ESCC and regulates cancer-related pathways. The gene discussed is GSK3B; the disease is cancer.