Furthermore, elevated levels of RPS8, RPL12, RPL23a, RPL27, and RPL30 mRNAs have been detected in human liver cancer tissues.6 Recent discoveries of RPL15 overexpression in circulating breast cancer tumor cells,7 and mutations of RPL5,8 RPL10,9 and RPS1510,11 in leukemia have inspired interest regarding how these RPs are associated with oncogenesis and disease progression. The gene discussed is RPL15; the disease is breast cancer.