The combination of 8 μM SB203580 and 0.5 μg/ml DDP resulted in inhibition of the proliferation of RPS15-overexpressing ESCC cells by as much as 69% for KYSE30 cells and 84.6% for KYSE450 cells compared with that of the controls, which represented a further inhibition of 42% for KYSE30 cells and 35.33% for KYSE450 cells compared with that of SB203580 alone (Fig. 4j, k). Here, RPS15 is linked to esophageal squamous cell carcinoma.