RPS15 and esophageal squamous cell carcinoma: Recent studies have refined the comprehension of biological aspects of RPs and reported that some RPLs and RPSs use specific translation pathways to promote tumor progression and drug resistance.7,33 In the current study, we screened all RPs using a CRISPR SAM system-based model and found that RPS15 played a key role in the development of ESCC.