C1QBP is an evolutionarily conserved protein and has been reported to promote homologous recombination by stabilizing MRE11 and controlling the assembly and activation of MRE11/RAD50/NBS1 complex, and the inhibition of C1QBP enhances the tumor regression with chemotherapy.44 RPS15 might interact with C1QBP to promote the DNA damage repair ability of ESCC cells and further promotes chemotherapy tolerance. The gene discussed is RAD50; the disease is esophageal squamous cell carcinoma.