Consistent with our findings in the whole sample, we found an up-regulation of pro-inflammatory and glucocorticoid-related genes in MDD cases vs. controls (A2M, CCL2, IL-1-beta, IL-6, MIF, FKBP5, SGK1, STAT1 and TNF-alpha), as well as the down-regulation of GR, as we described above. This evidence concerns the gene TNF and major depressive disorder.