In contrast, classic plasma inflammation-related (protein) cytokines (IL-6, IL-7, IL-8, IL-10, IL-12/IL-23p40, IL-17A and TNF-alpha) and absolute neutrophils count are different within the CRP-based MDD groups, following the same pattern of CRP, that is, higher in the CRP >3 group (vs. CRP <1 and/or controls). This evidence concerns the gene CXCL8 and major depressive disorder.