IL22 and colorectal carcinoma: For instance, Candida albicans can activate the interaction between macrophages and innate lymphoid cells, increase expression of IL‐22, and promote CRC.[77] Dysbiosis of gut fungi also affects the function of CARD9, thereby decreasing the activation of inflammasomes and maturation of IL‐18 and enhancing expansion of myeloid‐derived suppressor cells.