JAK2 and neoplasm: Notably, accumulating evidence has demonstrated an association between BA metabolism and CRC.[92] For example, CA and CDCA were found to regulate NF‐κB and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathways to promote CRC.[93] In addition, in N‐methyl‐N′nitro‐N‐nitrosoguanidine‐treated mice infusion of CA and CDCA caused a higher incidence of neoplasia in normal versus germ‐free mice, which highlights the key role of microbiota conversion of BAs in CRC progression.[94]