PHGDH and colorectal carcinoma: Phosphoglycerate dehydrogenase (PHGDH), a key enzyme in serine biosynthesis, can undergo monoubiquitination and increase activity in CRC cells, thereby increasing levels of serine, glycine, and S‐adenosylmethionine (SAM), which in turn upregulates cell adhesion gene expression and promotes cell migration and CRC metastasis.[143]