However, it was also reported that CCDC3 knockdown inhibits migration, proliferation, invasion, and EMT in cervical cancer cell lines (C33 and HeLa) that harbor either mutant p53 or degraded p53 via an E6-AP-mediated mechanism (Zhang et al., 2019), suggesting that CCDC3 might possess a mutant p53-dependent or wild-type p53-independent cancer-promoting action in these cells. This evidence concerns the gene TP53 and cervical cancer.