TP53 and neoplasm: Interestingly, ∼57% of CCDC3 mutations were detected at CCDC3 C-terminus, and 25.3% of the mutations were in the NLS region (Figure 4), supporting that CCDC3 is imported to the nucleus to activate p53 (Figure 3; Li et al., 2023a) and emphasizing the importance of CCDC3 C-terminus in its function as a tumor suppressor.